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History

THE HISTORY OF THE PEDIATRIC INFECTIOUS DISEASES DEPARTMENT

The students studied children’s infectious diseases at the Pediatric Department until 1965. The Pediatric Faculty was founded in 1965 and the separate course of children’s infectious diseases was organized and supervised by the assistant professor M.P. Dergilova.

In 1971 the course was transformed into the department. It was headed by Doctor of Medical Sciences, professor Kyrychenko Dmytro Fedorovych.

Professor, Doctor of Medical Sciences, Kyrychenko D.F.

Dmytro Fedorovych was born in Vinnytsia region in a peasant family. After graduating from high school in 1949, he entered Vinnytsia Medical Institute, which he graduated from in 1955 with honors. From 1956 to 1960 he studied at the Clinical residency and post-graduate school at the Infectious Diseases Department in Kyiv Medical Institute. He defended his Ph.D. thesis "Changes in the nervous system with typhoid fever, Botkin's disease, influenza and their clinical significance" in 1963 (the scientific supervisor was the head of the department B.Ya. Padalko).

Since 1961 – an assistant, Associate Professor of the Infectious Diseases Department at Vinnytsia Medical Institute.

In 1970 - he defended his doctoral dissertation "Epidemiological and clinical observations on cholera in Afghanistan".

Since 1971 –  the Head of Pediatric Infectious Department.

Since 1983 – the Head of the Infectious Diseases Department.

Since 1984 – Vice-Rector for Medical Work.

D.F. Kyrychenko was awarded with the Order of the Red Banner of Labour for a significant contribution to the elimination of the epidemic cholera outbreak in Odessa.

Prof. D.F. Kyrychenko has more than 150 scientific papers on the problems of cholera viral hepatitis, botulism, also he is a co-author of pediatric infectious diseases handbook, has prepared 5 candidates of sciences.

Since 2003 - Professor of the Infectious Diseases Department.

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         From 1983 till 1989 the special course was organized, consistently headed by the Associate Professor M.P. Dergilova and Associate Professor O. K. Kablukova.

Professor, Doctor of Medical Science, Kablukova O.K.

Olena Kasyanivna Kablukova graduated from the Pediatric Department at Lviv State Medical Institute in 1962.

In 1977 – an assistant of the Children’s Infectious Diseases Department at Vinnytsia Medical Institute.

In 1988 - she was elected to the position of Assistant Professor and the Head of the Children's Infections Course at Vinnytsia National Pirogov Memorial Medical University.

Kablukova O.K. has 208 scientific papers, 8 informative letters 6 methodical recommendations, 10 innovative proposals, 22 implementations in the medical process. Under her leadership, 9 candidate dissertations and 1 doctoral thesis were performed. She was the chairman of the regional branch of the Association of Pediatric Doctors, a member of the Certification Commission at Vinnytsia Health Care Administration.

In 1991, she successfully defended her doctoral dissertation "Changes in cell membranes in uncomplicated and complicated acute respiratory viral infections in children. Effectiveness of membrane-stabilizing agents".

In 1993 – Professor of the Children's Infectious Diseases Department.

In 1993 –the Head of the Pediatrics Department at Khmelnitsky Faculty of Physicians' Improvement.

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In 1989, the Department was opened again, which was headed by professor V.A. Kyrylenko.

Professor, Doctor of Medical Science, V.A. Kyrylenko.

Vadym Arseniiovych Kyrylenko (was born on July 27, 1930, Zhmerynka, Vinnytsia region) is an infectious disease doctor.

In 1989 he defended his doctoral dissertation "Clinical and epidemiological aspects of post-transfusion hepatitis B".

Since 1991 – Professor???

In 1956 he graduated from Vinnytsia Medical Institute, where he has been working since 1957 (now a university).

In 1989-2006 he was the head of the Children's Infectious Diseases Department.

A Corresponding Member of the International Academy of Integrative Anthropology (International Integrative Academy Anthropology). For a contribution to health care he was included in the Nomination for International Men of the Millennium (Cambridge Center for Biology, Cambridge CB2 3QP England Integrative Biographic Center).

He was awarded with the honorary token “Excellent worker in health care” (1971). Also he has the certificates of the Ministry of Health (1994, 2006).

Since 2017 - Professor of the Infectious Diseases Department.

Since 2006 the department has been headed by prof. І.І. Nezgoda.

Professor, Doctor of Medical Science, I.I. Nezgoda

Iryna Ivanivna is a Doctor of Medical Sciences, Professor, the Head of the the Children's Infectious Diseases Department at Vinnytsia National Pirogov Memorial Medical University.

In 1983 she graduated from the Pediatric Department of Vinnitsa Medical Institute.

In 1995 she defended her Ph.D. thesis on "Somatotype, dermatoglyphics and blood antibodies in children with stenotic laryngotracheitis"

In 2002 she defended her doctoral thesis "Salmonella infection in children. Clinical-genetic, morphological characteristics, modern approaches to treatment"

Nezgoda Iryna Ivanivna was born on June 18, 1960 (Lityn, Vinnytsia region), Ukrainian.

The milestones of professional work:

From 1977 to 1983 she studied at Vinnytsia Medical Institute at the Pediatric Faculty.

From 1983 to 1984 she worked as an intern at Khmelnitsky Central District Hospital.

From 1984 to 1985 - a district doctor-pediatrician.

From 1985 to 1988 - resident of Pediatric Infectious Diseases Hospital.

From 1988 to 1990 she studied at the Clinical Residency at Vinnytsia Medical Institute.

From 1990 - 2000 she was an assistant of the Children's Infectious Diseases Department;

2000-2004 - Associate Professor of the Children's Infectious Diseases Department;

November 26, 2004 - the Professor of the Children's Infectious Diseases Department.

Since July 1, 2006 and currently - the head of the Children's Infectious Diseases Department.

From 1991 to 1995 she was engaged in the problem of acute respiratory and viral infections complicated by acute stenotic laryngotracheitis development.

In 1995 she defended her Ph.D. thesis on "Somatotype, dermatoglyphics and blood antigens in patients with stenosing laryngotracheitis".

From 1996 to 2003 she worked on the topic of salmonella in young children. She studied pathomorphogenesis, features of clinical manifestation of septic forms of salmonellosis, as well as modern methods of diagnosis and treatment.

In 2003 she defended her doctoral dissertation "Salmonella infection in children – clinical, morphological and genetic characteristics, modern approaches to treatment".

Iryna Ivanivna is an active member of the Association of Infectionists of Ukraine since 2000. Since 2008, she has been a member of the European Society for Pediatric Infectious Diseases (ESPID), from 2015 - European Association for the Study of the Live.

Irina Ivanivna is a regional freelance infectious disease doctor since 2000. She was included in the working groups of the Ministry of Health for the development of clinical protocols with the diagnosis and treatment of chronic viral hepatitis B, C in children.

She is a member of the Specialized Academic Councils for the defense of dissertations: D 05.600.03 and D 05.600.04 at National Pirogov Memorial Medical University, Vinnytsia.

Iryna Ivanivna trained 4 candidates of Medical Science:

-                   Rykalo N.A. - "Features of the course and treatment of Salmonella and Klebsiellez in children, depending on the nature of the microflora of the biotope" 2005;

-                   Onofriichuk O.S. «Clinical and microbiological features of the course of salmonella gastrointestinal forms in children on the intestine colonization background by conditionally pathogenic microorganisms, modern approaches to treatment», 2007;

-                   Bodnariuk O.V. "Rotavirus infection in children: clinical and pathogenetic characteristics, ways to improve treatment" 2013;

-                   Naumenko O.M. "Pathogenetic mechanisms of development of rotavirus infection in children, modern approaches to treatment", 2017.

Irina Ivanivna heads the research work of the department "Metabolic and genetic aspects of the development of viral infections in children and modern methods of correction", on the study of rotavirus, noroviruses, viral hepatitis, Epstein-Barr viral infection, chicken pox in children.

Nezgoda Irina Ivanivna is the author of 253 printed works, including 2 monographs: "Viral Diarrhea in Children and Adults", 2011, Moscow and "Viral diarrhea", 2010, Kharkiv. She is a co-author of 2 textbooks: "A difficult diagnosis (the dead teach the living)" I.V. Bohadelnikov, A.V. Kubyshkina, I.I. Nezgoda and "Infectious diseases in children", Kyiv, 2016.

She is a co-author of "Atlas of infectious diseases" (M.A. Andreychyn, Nezgoda I.I.) Also she wrote manuals and methodical recommendations. She owns 8 patents for utility models.

Iryna Ivanivna was repeatedly awarded with certificates of honor for her significant contribution to the development of health care.

In 2015 she is a member of Infectionists Association of Ukraine

She was awarded with the medal of Agapit Pecherskyi for contributing to Infectious Diseases Prevention.

THE HISTORY OF THE PEDIATRIC INFECTIOUS DISEASES DEPARTMENT

In 1971, the head of the department together with associated professor Derhilova M.P., assistants Greshylo M.S., Valkova R.P. and Chekanova S.K. made a lot of effort to equip the main training base. On the basis of the disinfection station, a laboratory of the department was created (laboratory assistants M.Ya.Tloka, L. Galushko, the preparer V.Mulyk). The department was located on the base of the city children's infectious disease hospital, designed for 100 beds. Firstly, it occupied only 2 rooms (a lecture room and a training room). After reconstruction of the administrative department of the hospital, the number of study rooms was increased to 5. At present, the department is based on the Vinnytsia Regional Children's Infectious Diseases Hospital, which consists of the boxed department, calculated for 60 beds, and the intensive care unit is designed for 6 beds. The base of the Department of Children's Infectious Diseases consists of a cabinet of the Department Head, a cabinet of the associated professor and 6 classrooms. Also the Department Base consists of the receiving and diagnostic department, respiratory, intestinal infections, viral hepatitis and intensive care departments. The hospital and the department serve as the regional medical diagnostic center, where annually more than 4000 sick children receive assistance. The clinic is undergoing advanced training for doctors in city and district hospitals, seminars, clinic and anatomical conferences are held. The staff of the department leads the specialized assistance, conduct advisory work, take part in the certification of doctors, perform expert tasks of the Ministry of Health of Ukraine.

There are a lot of doctors who work at the Department: prof. І.І. Nezgoda (the Head of the Department), prof. L.M. Stanislavchuk, associated prof. O.S. Onofriichuk (PhD), Naumenko O. M. (PhD), assistants Levitskaya L.I., O.V. Nikluchenko, S.V. Bobruk, A.A. Asaulenko, laboratory assistant Skovlyuk I.V., laboratory assistant Minkin K.I. The department collaborates with the Association of Infectionists of Ukraine established in 1998 and actively participates in plenums, conferences, congresses, including congresses held in 1992, 2010 and 2015.

With the efforts of the Administration (the rector of National Pirogov Memorial Medical University – prof. V.M. Moroz), the Department of Infectious Diseases with the Course of Epidemiology (prof. L.V. Moroz), the Department of Children's Infectious Diseases (prof. I.I. Nezgoda) and other members of the Organizing Committee, VIII Congress of Infectionists of Ukraine: "Infectious Diseases: Achievements and Problems in Diagnosis and Therapy" was successfully held in Vinnytsia on October 6-8, 2010.

Students of V and VI courses of pediatric and medical faculty, foreign students, subordinates, interns, undergraduates, clinical residents, postgraduate students study at the department. The main approach in the study is to clinic and epidemiological examination of patients, purposeful appointment of medical and preventive measures. At the same time, methods of programmable learning and control, test tasks, visual materials in the form of tables, slides, educational films, bio preparations (vaccines, serums) are used. The lectures focus on the strategy and tactics of combating infectious diseases, the etiology, pathogenesis, clinics, diagnostics, treatment and prevention of common diseases. The ethical and deontological issues, the conscious attitude of young professionals to their professional and civic responsibilities are the proper place.

It should be noted that student youth finds significant interest in the subject. The student's scientific circle is functioning at the department, whose members regularly speak with the final reports at university and interuniversity conferences, and the 1st stage of Student Olympiad is held annually.

The scientific activity of the department is aimed at the practical solution of the problems of modern infectology, in particular acute infectious diseases in children. This is evidenced by the topics of planned works and theses devoted to the study of intestinal and respiratory infections, viral hepatitis, HIV/AIDS, and salmonellosis. On the basis of the obtained data, advanced methods of examination, treatment and prevention are offered.

Candidate and Doctoral Dissertations have been defeated for this period:

D. F. Kyrychenko "Epidemiological and Clinical Observations of Cholera in Afghanistan",

M.S. Greshil "Salmonellosis in Children and Adults" (1973).

V.F. Rudinskyi "Clinical and Pathogenetic peculiarities of viral hepatitis A in patients with persistent carrier of HB-antigen" (1987). The paper reflected scientific interests of prof. Kyrylenko, D.Med.Sc. Gavura, Ph.D. Rudinskyi, Ph.D. Ivanov (the problem of viral hepatitis).

V.A. Kyrylenko "Clinical and epidemiological aspects of post-transfusion viral hepatitis B" (1987); V. A. Kirilenko's monograph "Post-transfusion Viral Hepatitis" (Kyiv, Health, 1981).

The candidate's dissertation of V.M. Yuzhanina "Antibiotic therapy of acute pneumonia in the case of influenza and other acute respiratory infections" (1989) was devoted to acute respiratory diseases.

O.K. Kablukova's doctoral dissertation "Changes of cell membranes in uncomplicated and complicated respiratory viral diseases in children and effectiveness of drugs membrane stabilizing action "(1991).

Ph.D. thesis of I.I. Nezgoda "Somatotype, finger dermatoglyphics and antigens of blood in children with stenosing laryngotracheitis "(1995).

The doctoral dissertation of Stanislavchuk L.M. "Constrictive Laryngotracheitis in children. Epidemiology and Pathogenesis Features: differentiated approaches to treatment," devoted to the problem of recurrent laryngotracheitis in children.

The doctoral dissertation of associate professor I.I. Nezgoda "Salmonella Infection in young children (Clinical and Morphological and Genetic Characteristics, Modern Approaches to treatment)" (2002),

Candidate's thesis of O.S. Onofriichuk "Clinical and Microbiological Features of Salmonellosis in children with the intestine colonization by conditionally pathogenic microflora" (2007).

The growing relevance of rotavirus infection is demonstrated in the monographs "Viral Diarrhea" (V.P Malyi, I.I. Nezgoda and O.V. Bodnariuk) and "Viral Diarrhea in Children and Adults" (I.I. Nezgoda and O.V. Bodnariuk St. Petersburg, 2011).

Bodnariuk O.V. "Rotavirus Infection in children: Clinical and Pathogenetic characteristics, improving ways of treatment" 2013;

Naumenko O.M. "Pathogenetic mechanisms of development of Rotavirus Infection in children, modern approaches to treatment", 2017.

The dissertation research of the assistant Nikulchenko O.V., concerning the impression of the hepatotoxic biliary tract and pancreas in children suffering from rotavirus infection, continues to be performed.

In addition, new etiological factors of secretory diarrhea are studied, namely Noroviruses. Their specific gravity in the general structure of acute intestinal infections in children is studied with the help of modern diagnostic methods: immunohromatographic analysis (IHA) and ELISA, features of the clinical course are studied and modern approaches to treatment are developed.

Today, the question of the prevalence of Herpes infections in children, which by virtue of its immunosuppression and prolonged persistence in the body, creates a serious problem in pediatric infectology and pediatrics as a whole. The Department of Children's Infectious Diseases is engaged in the study of this topic at this time.

The dissertation work of Bobruk S.V. "Peculiarities of the Course and Treatment of Infectious Mononucleosis, depending on the microbiocinosis and immunology of the oropharyngeal zone in children" is being carried out, and the increase in morbidity and complicated flow of chicken pox at the present stage gave impetus to the planning of the dissertation Levitskaya L.I. "Pathogenetic Mechanisms of the Development of Smallpox in children, Modern Approaches to treatment».

One more global problem solved by the department is the problem of chronic viral Hepatitis. Nezgoda Iryna Ivanivna conducts dispensary supervision for patients with chronic hepatitis, conducts a specific etiotropic therapy with antiviral drugs. For the diagnosis of viral hepatitis, the most modern methods are used: PCR, molecular genetic research. Non-invasive methods for assessing the degree of liver fibrosis are actively used: Fibrotest, FiberMax, Acting. The increase in the proportion of chronic hepatitis in cancer patients was facilitated by the start of a new dissertation study by the assistant Singh Sh. "Mechanisms of Fibrosis Formation of the Liver in children suffering from viral Hepatitis B in the context of acute Leukemia: features of prognosis and treatment".

The results of scientific developments are regularly covered in the materials of the plenums of the Association of Infectious Diseases of Ukraine, in the journal "Infectious Diseases" and in other journals, as well as at congresses and conferences of infectious diseases and pediatricians. The staff of the department issued methodological recommendations, information letters, articles devoted to the methods of treatment and prevention of viral Hepatitis, Stenosing Laryngotracheitis with acute respiratory infections, Acute Intestinal Infections, Infectious Mononucleosis, Chicken Pox etc. The most original research is protected by copyright certificates.

In interaction with other departments and the Research Center of the University and practical health authorities in the medical practice functional virology and bacteriological examination of patients with viral hepatitis, enterovirus diseases, epidemic gastroenteritis, bacterial diarrheas were introduced. The clinic is widely used modern antibiotics, bio preparations, sorbents.

The staff of the department published methodological recommendations, info-letters, articles devoted to the methods of treatment and prevention of diphtheria, meningococcal infection, acute intestinal infections, infectious mononucleosis, viral hepatitis, HIV/AIDS.

On the initiative of the department, the use of modern methods of diagnosis of herpes viral infections (Herpes Simplex Virus (HSV½), Cytomegalovirus Infection (CMV), Epstein-Barr viral infection (EBV), viral Hepatitis by immune enzyme analysis (ELISA) and chains-polymerase reaction (PCR).

The department conducts clinical research of drugs: Nifuroxazid, Cardonate (Sperko), Hydrasek, Mamalak (Farmunion) and others.

During the years of its work, medicinal products have been introduced: antibiotics of the fluoroquinolone series, preparations: Laferon, Altan, Optismect, Hofitol, adapted mixture of NAN-Sour Milk, and NAN-Freeze, Nimesulide, Creon, Viferon, Geviran, Flavamed, Cefutil. Since 2006 in the complex treatment of cerebrospinal fluid and broncho-obstructive illnesses, nebulizer therapy with the use of the drugs "Flikosotid" and "Ventolin" has been introduced.

The introduction of more advanced methods of examination and treatment of patients affected the reduction in mortality from 1.7% in 1965, 0.4% in 1993, 0.11% in 2001 and 2011 to 0.05% - more than 30 times.

The global trend to increase the number of infectious diseases, changes in their course, the emergence of new unexplored forms of infections, necessitates the improvement of the educational process and the profound assimilation of the subject by future physicians.

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Department of Children's Infectious Diseases, VNMU named after. M.I. Pirogov is located at: street. Kiyvska, 68.

Email: child.infection@vnmu.edu.ua